Dimethylamine → N,N-Dimethyl-3-nitro-1H-pyrrol-2-amine

HRID 549228ノート

反応式

HRID 549228 の反応式
Cl[C:2]1[NH:3][CH:4]=[CH:5][C:6]=1[N+:7]([O-:9])=[O:8].[CH3:10][NH:11][CH3:12]>>[CH3:10][N:11]([CH3:12])[C:2]1[NH:3][CH:4]=[CH:5][C:6]=1[N+:7]([O-:9])=[O:8]

参加物

3

反応物 2

HCID 674DimethylamineHCID 553005692-chloro-3-nitro-1H-pyrrole

生成物 1

HCID 45121913N,N-Dimethyl-3-nitro-1H-pyrrol-2-amine

反応条件

温度
100 °C

実験手順

This compound was prepared in a manner analogous to that set forth in Step C of Example 2, using 0.65 gram (0.0045 mole) of 2-chloro-3-nitropyrrole (prepared in Steps D-F of Example 1) and 5.0 mL (excess) of dimethylamine. The microwave chemical reactor was maintained at 100° C. during a 45-minute period, after which time the reaction was considered to be complete. The crude product was purified with column chromatography on silica gel. Elution was accomplished using 25% hexane in diethyl ether, then 100% diethyl ether as eluants. The appropriate fractions were combined and concentrated under reduced pressure, yielding 0.2 gram of the subject compound. The NMR spectrum was consistent with the proposed structure.

後処理

  1. customThis compound was prepared in a manner analogous to that set forth in Step C of Example 2
  2. customThe crude product was purified with column chromatography on silica gel
  3. washElution
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-a8e431aa4fb14b27bcb644c66a0a0bbe
出典データセット
uspto-grants-2011_05
特許番号
US07943642B2

反応ノート

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