Benzyl Bromide → tert-Butyl-4-[2-(benzylsulfonyl)thieno[3,2-c]pyridin-4-yl]piperazine-1-carboxylate

関与物質

反応手順

Lithium 4-chlorothieno[3,2-c]pyridine-2-sulfinate (0.44 mmol) was treated with benzylbromide (0.59 mmol) as described in Method P above and then reacted further with tert-butyl-piperazine-1-carboxylate as described in Method Q. Yield 0.00 g (7% over two steps). Beige solid. 1H NMR (300 MHz, CDCl3) δ 8.14 (d, J=5.5 Hz 1H), 7.27-7.40 (m, 5H), 7.15-7.21 (m, 2H), 4.45 (s, 2H), 3.50-3.56 (m, 4H), 3.40-3.45 (m, 4H), 1.49 (s, 9H); MS (ESI+) for C23H27N3O4S2 m/z 474 (M+H)+. HPLC 77%, RT 3.93 min (ACE3 C8 50×4 mm, 5-50% acetonitrile in 3 min).

情報源と証拠