4-Butylbenzene-1-sulfonyl chloride → 1-(4-Butyl-benzenesulfonyl)-4-piperazin-1-yl-1H-pyrrolo(3,2-c)pyridine hydrochloride

HRID 549315

反応式

HRID 549315 の反応式
[CH3:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([Cl:14])(=[O:13])=[O:12])=[CH:7][CH:6]=1.[NH:15]1[C:23]2[CH:22]=[CH:21][N:20]=[C:19]([N:24]3[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]3)[C:18]=2[CH:17]=[CH:16]1>>[ClH:14].[CH2:4]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([N:15]2[C:23]3[CH:22]=[CH:21][N:20]=[C:19]([N:24]4[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]4)[C:18]=3[CH:17]=[CH:16]2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)[CH2:3][CH2:2][CH3:1]

参加物

3

反応物 2

HCID 27373524-Butylbenzene-1-sulfonyl chlorideHCID 671567091-Piperazinecarboxylic acid,4-(1h-pyrrolo[3,2-c]pyridin-4-yl)-,1,1-dimethylethyl ester

生成物 1

HCID 671572351-(4-Butyl-benzenesulfonyl)-4-piperazin-1-yl-1H-pyrrolo(3,2-c)pyridine hydrochloride

実験手順

4-N-Butylbenzenesulfonylchloride (30.0 mg) was added to tert-butyl 4-(1H-pyrrolo[3,2-c]pyridin-4-yl)piperazine-1-carboxylate the title compound (11.9 mg). LC/MS RT: 1.904 (System 10 till 40% MeCN over 1.5 min, ACE C8), Purity. 95%. MS: 400 (M+1) 1HNMR (CD3OD) δ ppm 0.90 (t, J=7.18 Hz, 3H) 1.31 (m, 2H) 1.55 (m, 2H) 2.67 (m, 2H) 3.50 (m, 4H) 4.09 (m, J=3.96 Hz, 4H) 7.25 (d, J=3.71 Hz, 2H) 7.44 (d, J=8.16 Hz, 2H) 7.91 (m, 2H) 8.02 (m, 2H).

出典と根拠

ORDレコード
ord-d0aa6496f43a462c9519242432755fb8
出典データセット
uspto-grants-2011_05
特許番号
US07943639B2

関連ノート

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