Boron tribromide → HCID 86614876、化合物

HRID 549497ノート

反応式

HRID 549497 の反応式
B(Br)(Br)Br.[Br:5][C:6]1[CH:7]=[CH:8][C:9]2[CH:10]=[CH:11][C:12]3[C:17]([C:18]=2[CH:19]=1)=[CH:16][C:15]([O:20]C)=[CH:14][CH:13]=3>C(Cl)Cl>[Br:5][C:6]1[CH:19]=[C:18]2[C:9](=[CH:8][CH:7]=1)[CH:10]=[CH:11][C:12]1[CH:13]=[CH:14][C:15]([OH:20])=[CH:16][C:17]2=1

参加物

4

反応物 2

HCID 25134Boron tribromideHCID 866148773-Bromo-6-methoxyphenanthrene

生成物 1

HCID 86614876HCID 86614876、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a flask containing BBr3 (1 M in CH2Cl2, 17 mL) at 0° C. was added a solution of 3-bromo-6-methoxyphenanthrene (1 g, 3.5 mmol) from Step 2, Example 160 in CH2Cl2 (10 mL). The reaction mixture was warmed to room temperature and stirred for 30 minutes, after which it was quenched with water. The aqueous layer was extracted with CH2Cl2. The organic layer was dried over MgSO4, filtered and concentrated to yield crude 6-bromophenanthren-3-ol.

後処理

  1. customafter which it was quenched with water
  2. extractionThe aqueous layer was extracted with CH2Cl2
  3. dry with materialThe organic layer was dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-690a5db960b14dc89152afdfa76eafc3
出典データセット
uspto-grants-2011_05
特許番号
US07943649B2

反応ノート

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