Sulfur → 2-(4-Fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine

HRID 54950

反応式

HRID 54950 の反応式
C([N:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)=[N:12][N:13]3[CH:18]=[CH:17][CH:16]=[N:15][C:14]=23)=[CH:6][CH:5]1[CH3:26])(=O)C.[S]>C1C2C(CCCC2)CCC1>[F:25][C:22]1[CH:23]=[CH:24][C:19]([C:11]2[C:10]([C:7]3[CH:8]=[CH:9][N:4]=[C:5]([CH3:26])[CH:6]=3)=[C:14]3[N:15]=[CH:16][CH:17]=[CH:18][N:13]3[N:12]=2)=[CH:20][CH:21]=1

参加物

4

反応物 2

HCID 5362487SulfurHCID 199572613-(1-Acetyl-l,2-dihydro-2-methylpyridin-4-yl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine

生成物 1

HCID 199572772-(4-Fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine収率 49.1%

試薬・触媒・溶媒 1

HCID 7044Decalin溶媒

反応条件

温度
190 °C

実験手順

A mixture of 3-(1-acetyl-1,2-dihydro-2-methylpyridin-4-yl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine (315 mg) and sulfur (146 mg) in decaline (3 ml) was stirred at 190° C. for 2 hours. The reaction mixture was cooled and purified by column chromatography on silica gel to give 2-(4-fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine (135 mg) as crystals.

後処理

  1. temperatureThe reaction mixture was cooled
  2. custompurified by column chromatography on silica gel

出典と根拠

ORDレコード
ord-3ed64ac8d49e4086a99c392c103b6c7c
出典データセット
uspto-grants-1997_04
特許番号
US05624931

関連ノート

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