化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 2-Benzoyl-4,5-dimethoxybenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 5,6-Dimethoxy-1,3-dihydro-2-benzofuran-1,3-dione | HCID 610356 | — |
| 反応物 | HCID 178478979 | HCID 178478979 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Benzoyl-4,5-dimethoxybenzoic acid | HCID 19957159 | 74.9% |
反応手順
Thirty grams (0.14 mole) of 4,5-dimethoxyphthalic anhydride was suspended in 300 mL of THF and 87 mL (0.17 mole) of phenylmagnesium chloride in THF was added over two hours. The reaction was stirred at room temperature for 14 hours, refluxed for two hours, cooled and poured into saturated ammonium chloride. The mixture was made acidic with 6N HCl, extracted into chloroform, dried over magnesium sulfate, concentrated to provide 30 g of 2-benzoyl-4,5-dimethoxybenzoic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05624922 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-43f8f20b41bd492a896d88ca1f42014d |
| 出典メモ | uspto-grants-1997_04 |