Hydrochloric Acid → 2-Benzoyl-4,5-dimethoxybenzoic acid

HRID 54976

反応式

HRID 54976 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[O:11])[O:9][C:7](=[O:8])[C:6]2=[CH:12][C:13]=1[O:14][CH3:15].[C:16]1([Mg]Cl)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[Cl-].[NH4+].Cl>C1COCC1>[C:7]([C:6]1[CH:12]=[C:13]([O:14][CH3:15])[C:3]([O:2][CH3:1])=[CH:4][C:5]=1[C:10]([OH:9])=[O:11])(=[O:8])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 25517Ammonium ChlorideHCID 6103565,6-Dimethoxy-1,3-dihydro-2-benzofuran-1,3-dioneHCID 178478979HCID 178478979、化合物

生成物 1

HCID 199571592-Benzoyl-4,5-dimethoxybenzoic acid収率 74.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Thirty grams (0.14 mole) of 4,5-dimethoxyphthalic anhydride was suspended in 300 mL of THF and 87 mL (0.17 mole) of phenylmagnesium chloride in THF was added over two hours. The reaction was stirred at room temperature for 14 hours, refluxed for two hours, cooled and poured into saturated ammonium chloride. The mixture was made acidic with 6N HCl, extracted into chloroform, dried over magnesium sulfate, concentrated to provide 30 g of 2-benzoyl-4,5-dimethoxybenzoic acid.

後処理

  1. temperaturerefluxed for two hours
  2. temperaturecooled
  3. extractionextracted into chloroform
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-43f8f20b41bd492a896d88ca1f42014d
出典データセット
uspto-grants-1997_04
特許番号
US05624922

関連ノート

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