関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 反応物 | 2,5-Dichlorobenzimidazole | HCID 335473 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | HCID 178452256 | HCID 178452256 | 40% |
反応手順
To 2,5-dichloro-1H-benzimidazole (100 mg, Synth. Commun, 1998, 28, 9, 1703-12) and Boc-piperazine (150 mg) was added dry EtOH (5 mL) and then triethylamine (0.112 mL) and the reaction was heated in a microwave at 150° C. for 1 h. The reaction was then heated further for 2.5 h at 170° C. The solvent was then evaporated in vacuo and the residue purified by column chromatography 30-100% EtOAC:hexanes to afford the title compound (72 mg) as a colourless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07943768B2 |
|---|
| 出典データセット | uspto-grants-2011_05 |
|---|
| ORD ID | ord-bc012cfab50645dc94a5427cbd3e46e4 |
|---|
| 出典メモ | uspto-grants-2011_05 |
|---|
