Hydrochloric Acid → 4-[4-(2-Phenylethyl)-1,3-thiazol-2-yl]piperidine hydrochloride

HRID 549947ノート

反応式

HRID 549947 の反応式
[ClH:1].[C:2]1([CH2:8][CH2:9][C:10]2[N:11]=[C:12]([CH:15]3[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)[S:13][CH:14]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(OCC)C>[ClH:1].[C:2]1([CH2:8][CH2:9][C:10]2[N:11]=[C:12]([CH:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[S:13][CH:14]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 67156379Tert-butyl 4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-carboxylate

生成物 1

HCID 671568834-[4-(2-Phenylethyl)-1,3-thiazol-2-yl]piperidine hydrochloride

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
0 °C

実験手順

At 0° C., a 2-molar solution of hydrogen chloride in diethyl ether is added dropwise to a solution of tert-butyl 4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-carboxylate (IV-1, 640 mg). The reaction mixture is stirred at 0° C. and then slowly warmed to room temperature. The mixture is stirred overnight, and the solvent and excess hydrogen chloride are then removed. This gives 4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidine hydrochloride (590 mg).

後処理

  1. temperatureslowly warmed to room temperature
  2. stirringThe mixture is stirred overnight
  3. customthe solvent and excess hydrogen chloride are then removed

出典と根拠

ORDレコード
ord-0269689c15454b4d813e4b1dc1e5e271
出典データセット
uspto-grants-2011_05
特許番号
US07943774B2

反応ノート

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