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HRID 549953作成日：2026年10月26日

2-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid → 1-{4-[5-Bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

https://huagongshe.com/reaction/549953

反応式

関与物質

役割名称HCID仕込み量
反応物2-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acidHCID 596118—
反応物4-[5-Bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidineHCID 67156856—
生成物1-{4-[5-Bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanoneHCID 67156400—

反応手順

4-[5-Bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidine (II-3, 127 mg) is reacted analogously to Example I-81 with [5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (118 mg). After chromatographic purification, this gives 1-{4-[5-bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (52 mg).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07943774B2
出典データセットuspto-grants-2011_05
ORD IDord-d75b1d47eb9449578b9109e441a24501
出典メモuspto-grants-2011_05