Ethanol → Ethyl 2-chloro-3-nitro-5-trifluoromethylbenzoate

HRID 550351ノート

反応式

HRID 550351 の反応式
[Cl:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:8]([C:14]([F:17])([F:16])[F:15])=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH2:18]([OH:20])[CH3:19]>>[Cl:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:8]([C:14]([F:17])([F:16])[F:15])=[CH:7][C:3]=1[C:4]([O:20][CH2:18][CH3:19])=[O:5]

参加物

3

反応物 2

HCID 702EthanolHCID 200341672-Chloro-3-nitro-5-trifluoromethylbenzoyl chloride

生成物 1

HCID 67200596Ethyl 2-chloro-3-nitro-5-trifluoromethylbenzoate

実験手順

The 2-chloro-3-nitro-5-trifluoromethylbenzoyl chloride (5.5 g; 18 mmol), obtained in step b) of Example 1, is dissolved in ethanol (50 ml) and stirred for 1 hour at room temperature. After evaporating to dryness, the pasty solid is purified by filtration on silica (eluent: dichloromethane). 4.2 g of ethyl 2-chloro-3-nitro-5-trifluoromethylbenzoate are obtained in the form of a pale yellow oil.

後処理

  1. customAfter evaporating to dryness
  2. filtrationthe pasty solid is purified by filtration on silica (eluent: dichloromethane)

出典と根拠

ORDレコード
ord-4ce5ae9eb8cb4074b6c19af214c5d9bf
出典データセット
uspto-grants-2011_05
特許番号
US07947675B2

反応ノート

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