反応式
[C:1]([C:3]1[C:4]([O:13][CH2:14][CH2:15][OH:16])=[N:5][NH:6][C:7]=1[N:8]=[CH:9][N:10](C)C)#[N:2].[CH3:17][O:18][C:19]1[CH:20]=[C:21]([CH:23]=[CH:24][C:25]=1[O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=1)N>>[CH3:17][O:18][C:19]1[CH:20]=[C:21]([NH:2][C:1]2[N:10]=[CH:9][N:8]=[C:7]3[NH:6][N:5]=[C:4]([O:13][CH2:14][CH2:15][OH:16])[C:3]=23)[CH:23]=[CH:24][C:25]=1[O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=1参加物
3
実験手順
The procedure described in Example 1 was repeated using N′-[4-cyano-3-(2-hydroxyethoxy)-1H-pyrazol-5-yl]-N,N-dimethylimidoformamide (200 mg, 0.9 mmol) and 3-methoxy-4-(pyridin-2-ylmethoxy)aniline (249 mg, 1.08 mmol) to give the title compound as a white solid (262 mg, 72%); NMR Spectrum: 3.80 (s+t, 5H), 4.31 (t, 2H), 5.15 (s, 2H), 7.04 (d, 1H), 7.16 (dd, 1H), 7.35 (s+d, 2H), 7.54 (d, 1H), 7.85 (t, 1H), 8.23 (s, 1H), 8.39 (s, 1H), 8.33 (s, 1H), 8.58 (d, 1H); Mass Spectrum: 409 (MH+).
出典と根拠
- ORDレコード
- ord-ab739f885e8c40f683aa9c4d52ed47f1
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07947676B2
関連ノート
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