4-Fluoropiperidine → HCID 11504233、化合物

HRID 550505

反応式

HRID 550505 の反応式
Cl[CH2:2][CH2:3][O:4][C:5]1[C:13]2[C:8](=[N:9][CH:10]=[N:11][C:12]=2[NH:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)=[C:17]([Cl:29])[CH:16]=2)[NH:7][N:6]=1.[F:30][CH:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>>[Cl:29][C:17]1[CH:16]=[C:15]([NH:14][C:12]2[N:11]=[CH:10][N:9]=[C:8]3[NH:7][N:6]=[C:5]([O:4][CH2:3][CH2:2][N:34]4[CH2:35][CH2:36][CH:31]([F:30])[CH2:32][CH2:33]4)[C:13]=23)[CH:20]=[CH:19][C:18]=1[O:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=1

参加物

3

反応物 2

HCID 27591594-FluoropiperidineHCID 115028913-(2-chloroethoxy)-N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

生成物 1

HCID 11504233HCID 11504233、化合物収率 38%

実験手順

The procedure described in Example 23 was repeated using 3-(2-chloroethoxy)-N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine (prepared as described in Example 13) and 4-fluoropiperidine to give the title compound in 38% yield; NMR Spectrum: 1.68-1.72 (m, 2H), 1.78-1.87 (m, 2H), 2.41-2.44 (m, 2H), 2.62-2.66 (m, 2H), 2.81 (t, 2H), 4.42 (t, 2H), 4.65 (dm, 1H), 5.29 (s, 2H), 7.24 (d, 1H), 7.36-7.38 (m, 1H), 7.55-7.58 (m, 2H), 7.85-7.91 (m, 2H), 8.29 (s, 1H), 8.51 (s, 1H), 8.59 (d, 1H); Mass Spectrum: 498 (MH+).

出典と根拠

ORDレコード
ord-3a35d22efde0491a8b2ebaca80407b5e
出典データセット
uspto-grants-2011_05
特許番号
US07947676B2

関連ノート

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