Methanol → Methyl 3-thiophenecarboxylate

HRID 550549

反応式

HRID 550549 の反応式
[S:1]1[CH:5]=[CH:4][C:3]([C:6]([OH:8])=[O:7])=[CH:2]1.S(=O)(=O)(O)O.[CH3:14]O>>[S:1]1[CH:5]=[CH:4][C:3]([C:6]([O:8][CH3:14])=[O:7])=[CH:2]1

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 6918Thiophene-3-carboxylic acid

生成物 1

HCID 574151Methyl 3-thiophenecarboxylate

実験手順

3-thiophenecarboxylic acid (2.0 g) was dissolved in MeOH (27 mL) and concentrated sulphuric acid (1.5 mL) was added. The reaction mixture was refluxed for 3 hours and 30 min., then concentrated under reduced pressure. A saturated NaHCO3 solution was added and the mixture was extracted with ethyl acetate. The organic phase was dried over Na2SO4 and concentrated in vacuo to give 1.98 g of the title compound as a colourless liquid which was used without further purification.

後処理

  1. temperatureThe reaction mixture was refluxed for 3 hours and 30 min.
  2. concentrationconcentrated under reduced pressure
  3. additionA saturated NaHCO3 solution was added
  4. extractionthe mixture was extracted with ethyl acetate
  5. dry with materialThe organic phase was dried over Na2SO4
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-8d3e5106c7154efaadb5a663b4df7f11
出典データセット
uspto-grants-2011_05
特許番号
US07947683B2

関連ノート

読み込み中…