4-Amino-2-methylpyridine → 3-bromo-N-(2-methylpyridin-4-yl)pyrazine-2-carboxamide

反応式

CO[C:3]([C:5]1[C:10]([Br:11])=[N:9][CH:8]=[CH:7][N:6]=1)=[O:4].[CH3:12][C:13]1[CH:18]=[C:17]([NH2:19])[CH:16]=[CH:15][N:14]=1>>[CH3:12][C:13]1[CH:18]=[C:17]([NH:19][C:3]([C:5]2[C:10]([Br:11])=[N:9][CH:8]=[CH:7][N:6]=2)=[O:4])[CH:16]=[CH:15][N:14]=1

参加物

反応物 2

HCID 7286704-Amino-2-methylpyridine

HCID 13318551Methyl 3-bromopyrazine-2-carboxylate

生成物 1

HCID 665243483-bromo-N-(2-methylpyridin-4-yl)pyrazine-2-carboxamide

実験手順

The title compound, MS: m/e=294.9 (M+H+), was prepared in accordance with the general method of example 1, step 2 from 3-bromo-pyrazine-2-carboxylic acid methyl ester (Example A) and 2-methyl-pyridin-4-ylamine (Example B).

出典と根拠

ORDレコード: ord-9e6845087a9145fb83768546d7e98e76
出典データセット: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07947685B2

反応ノート

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