Hydrazine → Methyl 3-amino-2,2-dimethylpropanoate

HRID 550595ノート

反応式

HRID 550595 の反応式
NN.O=C1C2C(=CC=CC=2)C(=O)[N:5]1[CH2:14][C:15]([CH3:21])([CH3:20])[C:16]([O:18][CH3:19])=[O:17]>CO.C(OCC)C>[NH2:5][CH2:14][C:15]([CH3:21])([CH3:20])[C:16]([O:18][CH3:19])=[O:17]

参加物

5

反応物 2

HCID 9321HydrazineHCID 11173032methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2,2-dimethylpropanoate

生成物 1

HCID 13285789Methyl 3-amino-2,2-dimethylpropanoate収率 75%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒

反応条件

温度
65 °C

実験手順

Hydrazine (1.1 eq., 0.27 mL, 8.42 mmol) was added to the solution of methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2,2-dimethylpropanoate (0.2 g, 7.66 mmol) in methanol (60 mL) maintained under magnetic stirring at 65° C. After 5 hours the reaction mixture was allowed to cool to room temperature, diluted with diethyl ether and filtered. The filtrate was washed thoroughly with diethyl ether. The title compound was obtained after evaporation of the solvents and it was used in the next step without any further purification. (0.8 g, 75% yield).

後処理

  1. temperaturemaintained
  2. temperatureto cool to room temperature
  3. filtrationfiltered
  4. washThe filtrate was washed thoroughly with diethyl ether

出典と根拠

ORDレコード
ord-32d89bb6a91c4421868a5048b955acc7
出典データセット
uspto-grants-2011_05
特許番号
US07947686B2

反応ノート

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