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4-Aminothiophenol → 2-(4-Aminophenylthio)-6-methoxyquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminothiophenol | HCID 14510 | — |
| 反応物 | 2-Dimethylaminopyridine | HCID 21885 | — |
| 反応物 | 2-Chloro-6-methoxyquinoline | HCID 83647 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(4-Aminophenylthio)-6-methoxyquinoline | HCID 18971662 | — |
反応手順
2-Chloro-6-methoxyquinoline (52.0 mmoles, 10.0 g), 4-aminothiophenol (52.0 mmoles, 6.5 g) and dimethylaminopyridine (52.0 mmoles, 6.3 g) were stirred for 16 hr in 250 ml ethanol. The reaction was condensed and purified by HPLC over silica gel eluted with 25-30% ethyl acetate/hexane to yield 2-(4-aminophenylthio)-6-methoxyquinoline. 8.5 g, 58% product. Mass spec (FD) 282. Calculated for C16H14N2OS: C, 68.06; H, 5.00, N, 9.92. Found: C, 68.04; H, 4.97; N, 10.02.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05624937 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-08c795c675d44ec988099b77cf02e9b6 |
| 出典メモ | uspto-grants-1997_04 |