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Toluene → 1-Pyrrolidineacetic acid, ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Ethyl bromoacetate | HCID 7748 | — |
| 反応物 | Pyrrolidine | HCID 31268 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-Pyrrolidineacetic acid, ethyl ester | HCID 210996 | — |
反応手順
To an ice bath-cooled solution of 213.4 g (3 mol) of pyrrolidine in 450 mL of tetrahydrofuran was added dropwise over about 2 hours 250.5 g (1.5 mol) of ethyl bromoacetate, maintaining the temperature below 30° C. To this solution was added 150 mL of toluene to precipitate pyrrolidinium bromide, which was separated by filtration. The filtrate was evaporated under vacuum to provide a residue of about 241 g of ethyl 1-pyrrolinidineacetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05244997 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-e8381d73f4f9423dbff70d4f1bb4f249 |
| 出典メモ | uspto-grants-1993_09 |