1,2-Dichloro-4-isothiocyanatobenzene → 1-[4-(2-Quinolylthio)phenyl]-3-(3,4-dichlorophenyl)thiourea

HRID 55093

反応式

HRID 55093 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=2)=[CH:4][CH:3]=1.[Cl:19][C:20]1[CH:21]=[C:22]([N:27]=[C:28]=[S:29])[CH:23]=[CH:24][C:25]=1[Cl:26]>>[N:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:17]=[CH:18][C:9]=1[S:8][C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:28]([NH:27][C:22]2[CH:23]=[CH:24][C:25]([Cl:26])=[C:20]([Cl:19])[CH:21]=2)=[S:29])=[CH:7][CH:6]=1

参加物

3

反応物 2

HCID 230651,2-Dichloro-4-isothiocyanatobenzeneHCID 226371302-(4-Aminophenylthio)quinoline

生成物 1

HCID 189716691-[4-(2-Quinolylthio)phenyl]-3-(3,4-dichlorophenyl)thiourea

実験手順

2-(4-Aminophenylthio)quinoline (11.9 moles, 3.0 g) and 3,4-dichlorophenylisothiocyanate (11.9 mmoles, 2.42 g) were reacted according to procedure B to yield the title compound, 360 mg, 6.6%. Mass Spec (FD) 455. Calculated for C22H15Cl2N3S2 : C, 57.90 H, 3.31; N, 9.21. Found: C, 57.86; H, 3.53; N, 9.07. m.p. 125°-126°.

出典と根拠

ORDレコード
ord-b5d135a5c74d43408848565d0bb40f3c
出典データセット
uspto-grants-1997_04
特許番号
US05624937

関連ノート

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