Potassium Carbonate → 2-(4-Nitrophenylthio)quinoline

HRID 55094

反応式

HRID 55094 の反応式
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[N+:12]([C:15]1[CH:20]=[CH:19][C:18]([SH:21])=[CH:17][CH:16]=1)([O-:14])=[O:13].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[N+:12]([C:15]1[CH:20]=[CH:19][C:18]([S:21][C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)=[CH:17][CH:16]=1)([O-:14])=[O:13]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 119282-ChloroquinolineHCID 158094-Nitrobenzenethiol

生成物 1

HCID 189716432-(4-Nitrophenylthio)quinoline収率 77%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2-Chloroquinoline (0.12 moles, 20.0 g), 4-nitrothiophenol (0.13 moles, 20.8 g), and potassium carbonate (0.13 moles, 18.5 g) were dissolved in 800 ml ethanol and stirred at room temperature for 1.5 hr. The mixture was filtered and the solid washed with ethanol. The solid was dissolved with ethyl acetate, washed with water, dried over sodium sulfate and concentrated to yield 2-(4-nitrophenylthio)quinoline 26.0 g, 77%. Mass Spec (FD) 282. Calculated for C15H10N2O2S: C, 63.82, H 3.57; N, 9.92. Found: C, 63.55, H 3.59; N, 9.71.

後処理

  1. filtrationThe mixture was filtered
  2. washthe solid washed with ethanol
  3. dissolutionThe solid was dissolved with ethyl acetate
  4. washwashed with water
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-7b51c3400761410e99d3cccc7aceea58
出典データセット
uspto-grants-1997_04
特許番号
US05624937

関連ノート

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