Urea → 4,6-dichloro-1,3-dihydro-2H-Imidazo[4,5-c]pyridin-2-one
反応式
[Cl:1][C:2]1[C:7]([NH2:8])=[C:6]([NH2:9])[CH:5]=[C:4]([Cl:10])[N:3]=1.N[C:12](N)=[O:13]>O>[Cl:1][C:2]1[C:7]2[NH:8][C:12](=[O:13])[NH:9][C:6]=2[CH:5]=[C:4]([Cl:10])[N:3]=1参加物
4
反応条件
- 温度
- 165 °C
実験手順
A mixture of 2,6-dichloro-3,4-dihydropyridine-3,4-diamine (500 mg, 2.8 mmol) from Step B and urea (1.0 g, 16.8 mmol) was stirred as a melt at 165° C. for 4 h, then cooled and H2O (100 mL) was added. The aqueous mixture was heated at reflux until all solid dissolved and the solution was allowed to cool and aged for 18 h. The precipitate was isolated by filtration to give the title compound. MS: m/z=205 (M+1).
後処理
- temperaturecooled
- temperatureThe aqueous mixture was heated
- temperatureat reflux until all solid
- dissolutiondissolved
- temperatureto cool
- waitaged for 18 h
- customThe precipitate was isolated by filtration
出典と根拠
- ORDレコード
- ord-ca2ec2b7a1a24ec797526d19ed8d5f68
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07947677B2
反応ノート
読み込み中…