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Hydrochloric Acid → 1-(4-Cyanobenzyl)imidazole-5-acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | [1-(4-Cyanobenzyl)-1H-imidazol-5-yl]acetic acid methyl ester | HCID 10634751 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-(4-Cyanobenzyl)imidazole-5-acetic acid | HCID 18433630 | — |
反応手順
A solution of [1-(4-cyanobenzyl)-1H-imidazol-5-yl]acetic acid methyl ester (4.44 g, 17.4 mmol ) in THF (100 ml) and 1M lithium hydroxide (17.4 ml, 17.4 mmol) was stirred at RT for 18 hr. 1M HCl (17.4 ml) was added and the THF was removed by evaporation in vacuo. The aqueous solution was lyophilized to afford the title compound containing lithium chloride as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05624936 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-0f7073cb653a437b995b8905a7eedf4b |
| 出典メモ | uspto-grants-1997_04 |