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2,6-Dichloropyridine → 2-Chloro-6-(3-thienylmethyloxy)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,6-Dichloropyridine | HCID 16989 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Thiophene-3-methanol | HCID 123570 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Chloro-6-(3-thienylmethyloxy)pyridine | HCID 19957413 | — |
反応手順
To a solution containing 3-thiophenemethanol (1.17 g, 0.010×1.0 mol) and sodium hydride (0.39 g, (ca.60% in mineral oil), 0.010×1.0 mol) in tetrahydrofuran, 2,6-dichloropyridine (1.5 g, 0.010 mol) was added and the resultant solution was refluxed for about 2 hours.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05624942 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-6773e5477f9c431ab909d7a6d265626e |
| 出典メモ | uspto-grants-1997_04 |