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3-(Trifluoromethyl)phenol → 2-(3-Thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Trifluoromethyl)phenol | HCID 7376 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2-Chloro-6-(3-thienylmethyloxy)pyridine | HCID 19957413 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(3-Thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine | HCID 19957405 | — |
反応手順
To a solution containing meta-trifluoromethylphenol (3.62 g, 0.0045×5.0 mol), sodium hydride (0.89 g, (Ca.60% in mineral oil), 0.0045×5.0 mol) and CuI (0.42 g, 0.0045×0.5 mol) in dimethylformamide, 2-chloro-6-(3-thienylmethyloxy)pyridine (1.0 g, 0.0045 mol) was added and the resultant solution was refluxed for about 3 hours.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05624942 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-6b619584c6cc4a48a4c6205325942da5 |
| 出典メモ | uspto-grants-1997_04 |