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3-(Trifluoromethyl)phenol → 4-Dimethylamino-2-(3-thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Trifluoromethyl)phenol | HCID 7376 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2-Chloro-4-dimethylamino-6-(3-thienylmethyloxy)pyridine | HCID 19957407 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | 4-Dimethylamino-2-(3-thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine | HCID 19957400 | — |
反応手順
To a solution of meta-trifluoromethylphenol (1.27 g, 0.0020×4.0 mol) in 20 ml of dry N,N-dimethylacetamide, sodium hydride (0.313 g, (ca.60% in mineral oil), 0.0020×4.0 mol) was added. After the bubbling ceased, a solution of 2-chloro-4-dimethylamino-6-(3-thienylmethyloxy)pyridine (0.526 g, 0.0020 mol) in 20 ml of dry N,N-dimethylacetamide was added dropwise, then CuI (0.186 g, 0.0020×0.5 mol) was added thereto and the resultant solution was stirred for 24 hours at the temperature of 170° to 180° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05624942 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-9d8ce96f1e2f4bf88603a54003fce961 |
| 出典メモ | uspto-grants-1997_04 |