HCID 66632589、化合物 → 4-methylnaphthalen-1-amine

HRID 551364ノート

反応式

HRID 551364 の反応式
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([N+:12]([O-])=O)=[CH:4][C:3]=1N>C(O)C.[Ni]>[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH2:12])=[CH:4][CH:3]=1

参加物

4

反応物 1

HCID 66632589HCID 66632589、化合物

生成物 1

HCID 4311874-methylnaphthalen-1-amine収率 96.9%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

To a solution of 1-methyl-4-nitro-naphthyl-amine (4.0 g, 21 mmol) in ethanol (300 mL) was added Raney-Nickel (4 scoops). The mixture was stirred under H2 (1 atm) for 16 h. The reaction was filtered through a pad of Celite and concentrated. Purification by silica gel flash column chromatography (EtOAc:Hexanes=15:85) provided product (3.2 g, 75%).

後処理

  1. filtrationThe reaction was filtered through a pad of Celite
  2. concentrationconcentrated
  3. customPurification by silica gel flash column chromatography (EtOAc:Hexanes=15:85)

出典と根拠

ORDレコード
ord-f600332730c940c8881763ee93bee8db
出典データセット
uspto-grants-2011_05
特許番号
US07947721B2

反応ノート

読み込み中…