Propylamine → 1,1,1-Trifluoro-3-[(6-methyl-1-phenyl-1H-indazol-4-yl)amino]-2-[(propylamino)methyl]-2-propanol
反応式
[CH2:1]([NH:3][CH2:4][C:5]([CH2:11][NH:12][C:13]1[CH:21]=[C:20]([CH3:22])[CH:19]=[C:18]2[C:14]=1[CH:15]=[N:16][N:17]2[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([OH:10])[C:6]([F:9])([F:8])[F:7])[CH3:2].[CH2:29](N)CC.CC1C=C(NCC2(C(F)(F)F)CO2)C2C=NN(C3C=CC=CC=3)C=2C=1>>[F:7][C:6]([F:9])([F:8])[C:5]([CH2:4][NH:3][CH2:1][CH2:2][CH3:29])([OH:10])[CH2:11][NH:12][C:13]1[CH:21]=[C:20]([CH3:22])[CH:19]=[C:18]2[C:14]=1[CH:15]=[N:16][N:17]2[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1参加物
4
反応物 3
生成物 1
実験手順
Prepared similarly to Intermediate 18 from n-propylamine and 6-methyl-1-phenyl-N-{[2-(trifluoromethyl)-2-oxiranyl]methyl}-1H-indazol-4-amine.