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2,2-Dimethylsuccinic anhydride → 4-[4-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-2,2-dimethyl-4-oxo-butyric acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,2-Dimethylsuccinic anhydride | HCID 87067 | — |
| 反応物 | 4-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-1H-indole | HCID 52939742 | — |
| 反応物 | 4-[4-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-4-oxo-butyric acid | HCID 52939743 | — |
| 生成物 | 4-[4-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-2,2-dimethyl-4-oxo-butyric acid | HCID 52939744 | — |
反応手順
4-[4-(4′,5′-Difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-2,2-dimethyl-4-oxo-butyric acid was synthesized by a procedure similar to 4-[4-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-4-oxo-butyric acid from starting materials 4-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-1H-indole and 2,2-dimethyl-succinic anhydride to yield the product as a white solid (13 mg, 27%). LC-MS (ES) calculated for C28H25F2NO5, 493.2; found m/z 494 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07947728B1 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-d4f3e0c4f47646cf8b62e07c8b7e0ed5 |
| 出典メモ | uspto-grants-2011_05 |