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Diisopropylamine → 4-(7-Bromo-3-isoquinolinyl)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylamine | HCID 7912 | — |
| 反応物 | 4-Ethynylbenzonitrile | HCID 4547245 | — |
| 反応物 | HCID 178448919 | HCID 178448919 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-(7-Bromo-3-isoquinolinyl)benzonitrile | HCID 67104258 | — |
反応手順
The product from Example 62D (3.6 mmol), 4-cyanophenylacetylene (4.3 mmol), CuI (0.2 mmol), PdCl2(PPh3)2 (0.1 mmol), and diisopropylamine (5.3 mmol) can be combined in toluene (15 mL) and processed as described in Example 62E to provide the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07947711B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-b4543ed2f70449f58d2f4ed17720778e |
| 出典メモ | uspto-grants-2011_05 |