1-Isopropylpiperazine → (4-Isopropyl-piperazin-1-yl)-[2-(2-piperidin-1-yl-ethylamino)-pyridin-4-yl]-methanone
反応式
Cl[C:2]1[CH:7]=[C:6]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([CH:16]([CH3:18])[CH3:17])[CH2:12][CH2:11]2)=[O:9])[CH:5]=[CH:4][N:3]=1.Cl[C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][N:28]=1)C(O)=O.[CH:29]([N:32]1CCNCC1)(C)[CH3:30]>>[CH:16]([N:13]1[CH2:14][CH2:15][N:10]([C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:32][CH2:29][CH2:30][N:28]3[CH2:20][CH2:21][CH2:22][CH2:26][CH2:27]3)[CH:7]=2)=[O:9])[CH2:11][CH2:12]1)([CH3:18])[CH3:17]参加物
4
実験手順
(2-Chloro-pyridin-4-yl)-(4-isopropyl-piperazin-1-yl)-methanone. The title compound was prepared in a manner similar to that described in Step A of Example 9 using 2-chloro-isonicotinic acid and 1-isopropyl-piperazine.