Hydrochloric Acid → 5-(2-Aminoethyl)-2-methoxyphenylamine

HRID 551603ノート

反応式

HRID 551603 の反応式
Cl.[NH2:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][NH:13]C(=O)C)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Cl>>[NH2:13][CH2:12][CH2:11][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([NH2:2])[CH:4]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 45074592N-(3-Amino-4-methoxyphenethyl)acetamide hydrochloride

生成物 1

HCID 233197675-(2-Aminoethyl)-2-methoxyphenylamine収率 94%

実験手順

N-[-2-(3-amino-4-methoxyphenyl)ethyl]acetamide hydrochloride, prepared as described in Example 8 (15 g) and 175 mL of 2N HCl were heated at reflux for 6 hours. The solvent was removed by rotary evaporation, and the residue was washed with ethanol. The resulting white precipitate was filtered off and dried in vacuum, yielding 13.7 g (94%) of 5-(2-aminoethyl)-2-methoxyphenylamine (AMMPA) dihydrochloride as white crystals. 1HNMR (DMSO-d6) spectrum was consistent with the desired product.

後処理

  1. temperaturewere heated
  2. temperatureat reflux for 6 hours
  3. customThe solvent was removed by rotary evaporation
  4. washthe residue was washed with ethanol
  5. filtrationThe resulting white precipitate was filtered off
  6. customdried in vacuum

出典と根拠

ORDレコード
ord-2e7c11cc7b2848d7b50355063670ea45
出典データセット
uspto-grants-2011_05
特許番号
US07947761B2

反応ノート

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