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2-(Trifluoromethyl)benzoic acid → 2-(Trifluoromethyl)benzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Trifluoromethyl)benzoic acid | HCID 9899 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 生成物 | 2-(Trifluoromethyl)benzoyl chloride | HCID 67561 | — |
反応手順
A solution of 2.0 g of o-trifluoromethylbenzoic acid in 21 ml of thionyl chloride is heated at reflux for 1 hour. The volatiles are evaporated in vacuo to give a residue which is concentrated from toluene three times and dried under vacuum to give 2.1 g of the desired product as a residue.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05624923 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-c43ea7ec0d574071b997e0cd52b06fb1 |
| 出典メモ | uspto-grants-1997_04 |