Dichloromethane → ethyl 1-(3,4-dihydroquinolin-1(2H)-ylcarbonyl)piperidine-4-carboxylate

HRID 551791ノート

反応式

HRID 551791 の反応式
[I-].[N:2]1([C:12]([N:14]2[CH:18]=[CH:17][N+](C)=[CH:15]2)=[O:13])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH2:3]1.ClCCl.N1CC[CH:26]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[CH2:25]C1>C(N(CC)CC)C>[N:2]1([C:12]([N:14]2[CH2:15][CH2:25][CH:26]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[CH2:17][CH2:18]2)=[O:13])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH2:3]1

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 70770Ethyl 4-piperidinecarboxylateHCID 109595761-(3,4-Dihydroquinolin-1(2H)-ylcarbonyl)-3-methyl-1H-imidazol-3-ium Iodide

生成物 1

HCID 67188549ethyl 1-(3,4-dihydroquinolin-1(2H)-ylcarbonyl)piperidine-4-carboxylate

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

16.5 g of 1-(3,4-dihydroquinolin-1(2H)-ylcarbonyl)-3-methyl-1H-imidazol-3-ium iodide, 224 ml of dichloromethane and 8.45 g of ethyl isonipecotate, followed by 31.22 ml of triethylamine, are introduced into a 500 ml round-bottomed flask. The reaction medium is stirred at ambient temperature for 20 hours. The solvent is evaporated under reduced pressure and the residue is taken up in ethyl acetate and then washed with water. The organic phase is dried over sodium sulfate and the solvent is evaporated under reduced pressure to result in 15.2 g of ethyl 1-(3,4-dihydroquinolin-1(2H)-ylcarbonyl)piperidine-4-carboxylate.

後処理

  1. additionare introduced into a 500 ml round-bottomed flask
  2. customThe solvent is evaporated under reduced pressure
  3. washwashed with water
  4. dry with materialThe organic phase is dried over sodium sulfate
  5. customthe solvent is evaporated under reduced pressure
  6. customto result in 15.2 g of ethyl 1-(3,4-dihydroquinolin-1(2H)-ylcarbonyl)piperidine-4-carboxylate

出典と根拠

ORDレコード
ord-fbfd70cf10784e6ea6e2b306b0312358
出典データセット
uspto-grants-2011_05
特許番号
US07947834B2

反応ノート

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