Hydrochloric Acid → 4-Difluoromethylene-1,2,3,4-tetrahydroquinoline
反応式
[F:1][C:2]([F:21])=[C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6](NC(OC(C)(C)C)=O)[CH2:5][CH2:4]1.Cl>ClCCl.O1CCOCC1>[F:21][C:2]([F:1])=[C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH2:5][CH2:4]1参加物
5
実験手順
0.11 g of tert-butyl 4-difluoromethylene-3,4-dihydro-2H-quinoline-1-carbamate in 10 ml of dichloromethane is introduced into a round-bottomed flask equipped with a magnetic stirrer. 6 ml of a 4N solution of hydrochloric acid in dioxane are added. After stirring at ambient temperature for 6 h, the reaction medium is concentrated under vacuum. 0.07 g of 4-difluoromethylene-1,2,3,4-tetrahydroquinoline is obtained.
後処理
- customequipped with a magnetic stirrer
- concentrationthe reaction medium is concentrated under vacuum
出典と根拠
- ORDレコード
- ord-c8c833fb7b7c40809e09c89c00275c69
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07947834B2
反応ノート
読み込み中…