4-(Phenylethynyl)benzaldehyde → Methyl 2-fluoro-5-{[4-(phenylethynyl)benzyl]amino}benzoate

HRID 551942ノート

反応式

HRID 551942 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:12])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[C:13]1([C:19]#[C:20][C:21]2[CH:28]=[CH:27][C:24]([CH:25]=O)=[CH:23][CH:22]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[F:12][C:5]1[CH:4]=[CH:3][C:2]([NH:1][CH2:25][C:24]2[CH:27]=[CH:28][C:21]([C:20]#[C:19][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:22][CH:23]=2)=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8]

参加物

3

反応物 2

HCID 6099084-(Phenylethynyl)benzaldehydeHCID 15621043Methyl 5-amino-2-fluorobenzoate

生成物 1

HCID 57554560Methyl 2-fluoro-5-{[4-(phenylethynyl)benzyl]amino}benzoate

実験手順

The title compound was prepared following the procedure described in Example 23 step a) using methyl 5-amino-2-fluorobenzoate (500 mg, 2.96 mmol) and 4-(phenylethynyl)benzaldehyde (Fluorochem, 640 mg, 3.10 mmol). The title compound was obtained as a white powder (717 mg, 68%). HPLC, Rt: 4.78 min (purity: 97.4%). LC/MS, M−(ESI): 358.1. 1H NMR (CDCl3) δ: 7.52-7.48 (m, 4H), 7.32 (m, 5H), 7.15 (dd, J=5.3, 3.1 Hz, 1H), 6.94 (dd, J=10.5, 9.2 Hz, 1H), 6.72 (m, 1H), 4.33 (s, 2H), 3.89 (s, 3H).

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-48bc8eb06a8b41799d9f8ce7f80e0903
出典データセット
uspto-grants-2011_05
特許番号
US07947851B2

反応ノート

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