Water → ((2-Chloroethyl)thio)benzene

HRID 552043

反応式

HRID 552043 の反応式
[C:1]1([SH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O-]CC.[Na+].Br[CH2:13][CH2:14][Cl:15].O>C(O)C>[C:1]1([S:7][CH2:13][CH2:14][Cl:15])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

6

反応物 4

HCID 962WaterHCID 78491-Bromo-2-ChloroethaneHCID 7969ThiophenolHCID 2723922Sodium ethoxide

生成物 1

HCID 21702((2-Chloroethyl)thio)benzene収率 74%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

Benzenethiol (15.0 g, 0.136 mol) was added to the solution of sodium ethoxide (0.20 mol) in 200 ml of anhydrous ethanol, and the mixture was stirred at room temperature for 15 minutes and then added to the solution of 1-bromo-2-chloroethane in 100 ml of ethanol. The resultant mixture was stirred at room temperature for 3 hours and poured into 300 ml of water. The mixture was extracted three times with ether and the combined organic layer was dried over magnesium sulfate. After removal of the solvent, the compound was purified by flash chromatography using heptane/ethyl acetate (100 to 97/3) as eluent in a yield of 74%.

後処理

  1. extractionThe mixture was extracted three times with ether
  2. dry with materialthe combined organic layer was dried over magnesium sulfate
  3. customAfter removal of the solvent
  4. customthe compound was purified by flash chromatography

出典と根拠

ORDレコード
ord-815b378299de4a13abaaa97f6fcc2e5c
出典データセット
uspto-grants-2011_05
特許番号
US07951550B2

関連ノート

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