1-Bromo-2-Chloroethane → 1,3-Dibromo-2-(2-chloroethoxy)benzene

A solution comprising 2,6-dibromophenol (3.90 g, 15.00 mmol), potassium carbonate (2.48 g, 17.94 mmol) and DMF (40 ml) was added with 1-bromo-2-chloro ethane (4.30 g, 29.98 mmol) and stirred at room temperature for 16 hours. The reaction solution was concentrated and liquid separation was carried out with ethyl acetate-water. The organic layer was washed with saturated sodium chloride water and dried with anhydrous sodium sulfate. The residue obtained by concentration was purified by silica gel column chromatography (n-hexane) to obtain the target compound (4.75 g, quant.) as a colorless oily substance.

1. concentrationThe reaction solution was concentrated
2. customliquid separation
3. washThe organic layer was washed with saturated sodium chloride water
4. dry with materialdried with anhydrous sodium sulfate
5. customThe residue obtained by concentration
6. customwas purified by silica gel column chromatography (n-hexane)
7. customto obtain the target compound (4.75 g, quant.) as a colorless oily substance

ORDレコード

ord-9b0bbbb9ec794185867fefed5ca2f758

出典データセット

uspto-grants-2011_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07951799B2