Hydrochloric Acid → 2-Aminopyrimidine-4-carbaldehyde

HRID 552114ノート

反応式

HRID 552114 の反応式
C[O:2][CH:3](OC)[C:4]1[CH:9]=[CH:8][N:7]=[C:6]([NH2:10])[N:5]=1.Cl.C([O-])(O)=O.[Na+]>CCOC(C)=O>[NH2:10][C:6]1[N:5]=[C:4]([CH:3]=[O:2])[CH:9]=[CH:8][N:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 49130324-(dimethoxymethyl)pyrimidin-2-amine

生成物 1

HCID 178323462-Aminopyrimidine-4-carbaldehyde収率 37.3%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 2.5 g (15 mmol, 1.0 eq.) of 2-aminopyrimidine-4-carboxaldehyde dimethylacetal (I-8) in 16 mL (48 mmol, 3.2 eq.) of 3M HCl was heated at 48° C. for 14 h. The mixture was allowed to cool to room temperature and diluted with 50 mL of EtOAc. The aqueous layer was neutralized with NaHCO3 and then extracted with EtOAc (5×50 mL). The combined organic extracts were dried (Na2SO4) and the solvent removed in vacuo to provide 0.69 g (5.6 mmol, 37%) of 2-aminopyrimidine-4-carboxaldehyde (I-9) as a yellow solid.

後処理

  1. extractionextracted with EtOAc (5×50 mL)
  2. dry with materialThe combined organic extracts were dried (Na2SO4)
  3. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-8d1c69c2c51a44118c5950aa007bf96e
出典データセット
uspto-grants-2011_05
特許番号
US07951803B2

反応ノート

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