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1-(4-Nitrobenzyl)piperidine → 4-(Piperidin-1-ylmethyl)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(4-Nitrobenzyl)piperidine | HCID 783541 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-(Piperidin-1-ylmethyl)aniline | HCID 846150 | — |
反応手順
To a solution of 0.22 g (1.0 mmol, 1.0 eq.) of 1-(4-nitrobenzyl)piperidine (I-27) in 20 mL of THF was added ˜30 mg of Raney Nickel. The reaction mixture was stirred under at room temperature under 1 atm. of hydrogen for 12 h. The reaction mixture was through Celite® and the solvent removed in vacuo to provide 4-(piperidin-1-ylmethyl)benzenamine (I-28).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07951803B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-92dcc1ce91b347c7bc84e34fbff6c632 |
| 出典メモ | uspto-grants-2011_05 |