Water → 3-Amino-5-chloro-1,3-dihydro-3-(2-methoxyphenyl)indol-2-one

HRID 552305ノート

反応式

HRID 552305 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2(O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH2:19]CC.[NH3:23].C(O)C.O>C(Cl)Cl>[NH2:23][C:5]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([Cl:1])[CH:3]=2)[NH:7][C:6]1=[O:11]

参加物

5

反応物 3

HCID 962WaterHCID 22020343Ethanol, reaction products with ammonia, distn. residuesHCID 574664415-Chloro-3-hydroxy-3-(2-propoxyphenyl)-indole-2-one

生成物 1

HCID 219254143-Amino-5-chloro-1,3-dihydro-3-(2-methoxyphenyl)indol-2-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

10 g (32.45 mmol) of the intermediate product 2a were suspended in 100 ml methylene chloride. After the addition of 100 ml 2-molar ethanol ammonia solution, the reaction mixture was stirred for 16 h. After this, everything was poured on to icy water and the organic phase was separated. The aqueous phase was cooled, wherein a white crystallizate formed, which was isolated. 5.7 g of the product were obtained.

後処理

  1. customthe organic phase was separated
  2. temperatureThe aqueous phase was cooled, wherein a white crystallizate
  3. customformed
  4. customwhich was isolated

出典と根拠

ORDレコード
ord-4b674444487e4431b31cbc0f5c655a05
出典データセット
uspto-grants-2011_05
特許番号
US07951807B2

反応ノート

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