Ammonia → 4-Bromoisoindolin-1-one

HRID 552391ノート

反応式

HRID 552391 の反応式
[NH3:1].C[O:3][C:4](=O)[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Br:11])[C:6]=1[CH2:12]Br>CO>[Br:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:5]2[C:6]=1[CH2:12][NH:1][C:4]2=[O:3]

参加物

4

反応物 2

HCID 222Ammonia2 回HCID 21907554Methyl 3-bromo-2-(bromomethyl)benzoate

生成物 1

HCID 219075094-Bromoisoindolin-1-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

In a 25 mL microwave tube 3-bromo-2-bromomethyl-benzoic acid methyl ester is dissolved in methanol (15 mL) and mixed with 7.0M methanolic ammonia (6.3 mL) and 17.0M aqueous ammonia (7.3 mL). The microwave tube is sealed and the mixture is stirred overnight at room temperature. The precipitate formed is filtered out and washed with cold water, then dried under vacuum to afford the title compound.

後処理

  1. customThe microwave tube is sealed
  2. customThe precipitate formed
  3. filtrationis filtered out
  4. washwashed with cold water
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-7fb216503ba340cca3edfc6422d298d0
出典データセット
uspto-grants-2011_05
特許番号
US07951818B2

反応ノート

読み込み中…