ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Diethyl Ether → (7R)-7-Amino-4-chloro-9-(2,2,2-trifluoroethyl)-6,7,9,10-tetrahydroazepino[3,4-e]indazol-8(3H)-one bis-methanesulfonate

HRID 552568
ノート
印刷プレビュー

反応式

HRID 552568 の反応式
C(OC(=O)[NH:10][C@H:11]1[C:25](=[O:26])[N:24]([CH2:27][C:28]([F:31])([F:30])[F:29])[CH2:23][C:14]2[C:15]3[CH:16]=[N:17][NH:18][C:19]=3[C:20]([Cl:22])=[CH:21][C:13]=2[CH2:12]1)C1C=CC=CC=1.C1(OC)C=CC=CC=1.[CH3:41][S:42]([OH:45])(=[O:44])=[O:43].CCOCC>C(Cl)Cl>[CH3:41][S:42]([OH:45])(=[O:44])=[O:43].[CH3:41][S:42]([OH:45])(=[O:44])=[O:43].[NH2:10][C@H:11]1[C:25](=[O:26])[N:24]([CH2:27][C:28]([F:29])([F:31])[F:30])[CH2:23][C:14]2[C:15]3[CH:16]=[N:17][NH:18][C:19]=3[C:20]([Cl:22])=[CH:21][C:13]=2[CH2:12]1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 3283Diethyl EtherHCID 6395Methanesulfonic AcidHCID 7519AnisoleHCID 59732091(R)-Benzyl 4-chloro-8-oxo-9-(2,2,2-trifluoroethyl)-3,6,7,8,9,10-hexahydroazepino[3,4-e]indazol-7-ylcarbamate

生成物 1

HCID 86640003(7R)-7-Amino-4-chloro-9-(2,2,2-trifluoroethyl)-6,7,9,10-tetrahydroazepino[3,4-e]indazol-8(3H)-one bis-methanesulfonate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a mixture of benzyl[(7R)-4-chloro-8-oxo-9-(2,2,2-trifluoroethyl)-3,6,7,8,9,10-hexahydroazepino[3,4-e]indazol-7-yl]carbamate from Step A (265 mg, 0.568 mmol) and anisole (184 mg, 1.70 mmol) in CH2Cl2 (4 mL) was added methanesulfonic acid (1.84 mL, 28 mmol). The resulting mixture was stirred at ambient temperature for 45 min, Et2O (45 mL) was added, and stirring was continued for 20 min. The supernatant was removed and the residue was washed with Et2O and dried in vacuo to give the title compound. MS: m/z=333.

後処理

  1. stirringstirring
  2. waitwas continued for 20 min
  3. customThe supernatant was removed
  4. washthe residue was washed with Et2O
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-ab5af4adb1ac466bbc1ec3bb9fbe800b
出典データセット
uspto-grants-2011_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07951795B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート