Methanol → Methyl 2-(4-bromophenyl)acetate

HRID 55295ノート

反応式

HRID 55295 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[CH3:12]O>>[CH3:12][O:10][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=1

参加物

3

反応物 2

HCID 887MethanolHCID 74654Benzeneacetic acid, 4-bromo-

生成物 1

HCID 316783Methyl 2-(4-bromophenyl)acetate

実験手順

A solution of 100 g of 4-bromophenylacetic acid in 1.5 l of methanol is mixed with 232 g of Amberlyst 15, and the suspension is stirred for 48 hours at room temperature. The reaction mixture is suctioned off on diatomaceous earth, the filter residue is washed with dichloromethane, and the filtrate is concentrated by evaporation. The residue is taken up in ethyl acetate, washed with 10% sodium bicarbonate solution and saturated common salt solution, dried on sodium sulfate and concentrated by evaporation. 106 g of 4-bromophenylacetic acid methyl ester is obtained as oil.

後処理

  1. washthe filter residue is washed with dichloromethane
  2. concentrationthe filtrate is concentrated by evaporation
  3. washwashed with 10% sodium bicarbonate solution and saturated common salt solution
  4. customdried on sodium sulfate
  5. concentrationconcentrated by evaporation

出典と根拠

ORDレコード
ord-685cd69b188c4f41905437882c80882f
出典データセット
uspto-grants-1997_04
特許番号
US05624943

反応ノート

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