化工社化工社 化学情報印刷レポート · 研究参考用
Trimethylsilylacetylene → Methyl 5-((trimethylsilyl)ethynyl)nicotinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trimethylsilylacetylene | HCID 66111 | — |
| 反応物 | Methyl 5-bromopyridine-3-carboxylate | HCID 699336 | — |
| 生成物 | Methyl 5-((trimethylsilyl)ethynyl)nicotinate | HCID 53821751 | 13.6% |
反応手順
Under the conditions of example 21 B, 5 g of 5-bromonicotinic acid methyl ester is reacted with 2.43 g of trimethylsilylacetylene, worked up, and the crude product is chromatographed on silica gel with hexane/0-5% ethyl acetate. 734 mg of 5-(2-trimethlsilylethinyl)-nicotinic acid methyl ester is obtained as oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05624943 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-b32f6a6c03b1401f8f6ebe00916729cb |
| 出典メモ | uspto-grants-1997_04 |