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4-Pentyn-1-ol → 3-[3-Hydroxy-6-(5-hydroxy-1-pentynyl)-2-pyridyl]-propionic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Pentyn-1-ol | HCID 79346 | — |
| 反応物 | 3-(3-Hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester | HCID 54475019 | — |
| 生成物 | 3-[3-Hydroxy-6-(5-hydroxy-1-pentynyl)-2-pyridyl]-propionic acid methyl ester | HCID 54397879 | 28% |
反応手順
Under the conditions of example 5 A, 5 g of 3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester is reacted with 1.37 g of 4-pentyn-1-ol, worked up, and the crude product is chromatographed on silica gel with hexane/0-4% methanol. 1.2 g of 3-[3-hydroxy-6-(5-hydroxy-1-pentynyl)-2-pyridyl]-propionic acid methyl ester is obtained as colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05624943 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-3041615f29b8409b826be1c81f949e26 |
| 出典メモ | uspto-grants-1997_04 |