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3-Ethynylbenzoic acid methyl ester → 3-{3-Hydroxy-6-[2-(3-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Ethynylbenzoic acid methyl ester | HCID 11275159 | — |
| 反応物 | 3-(3-Hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester | HCID 54475019 | — |
| 生成物 | 3-{3-Hydroxy-6-[2-(3-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester | HCID 54492341 | 46.2% |
反応手順
Under the conditions of example 5A, 9.2 g of 3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester is reacted with 4.8 g of 3-ethinylbenzoic acid methyl ester, worked up, and the crude product is chromatographed on silica gel with hexane/0-20% ethyl acetate. 4.7 g of 3-{3-hydroxy-6-[2-(3-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester of melting point 125°-127° C. is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05624943 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-544f5b679e534578886630149d855777 |
| 出典メモ | uspto-grants-1997_04 |