1,5-Diazocane → 1-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-yl]-1,5-diazacyclooctane

HRID 55317ノート

反応式

HRID 55317 の反応式
Br[C:2]1[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[C:5]2[CH:15]=[CH:16][CH:17]=[CH:18][C:4]=2[N:3]=1.[NH:19]1[CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21][CH2:20]1>>[F:14][C:11]1[CH:12]=[CH:13][C:8]([CH2:7][N:6]2[C:5]3[CH:15]=[CH:16][CH:17]=[CH:18][C:4]=3[N:3]=[C:2]2[N:19]2[CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21][CH2:20]2)=[CH:9][CH:10]=1

参加物

3

反応物 2

HCID 52483731,5-DiazocaneHCID 199575402-Bromo-1-[(4-fluorophenyl)methyl]-1H-benzimidazole

生成物 1

HCID 199575511-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-yl]-1,5-diazacyclooctane収率 108.3%

反応条件

温度
80 °C

実験手順

A mixture of 2-bromo-1-(4-fluorophenylmethyl)-1H-benzimidazole (10.07 g) and 1,5-diazacyclooctane (5.60 g) was heated at 80° C. for 1 hour. To the reaction mixture was added distilled water (300 ml), and the mixture was extracted with methylene chloride (300 ml). The extract was washed with water, and dried over anhydrous MgSO4. The solvent was removed under reduced pressure to give 1-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-yl]-1,5-diazacyclooctane (12.1 g) as a colorless oily liquid.

後処理

  1. additionTo the reaction mixture was added
  2. distillationdistilled water (300 ml)
  3. extractionthe mixture was extracted with methylene chloride (300 ml)
  4. washThe extract was washed with water
  5. dry with materialdried over anhydrous MgSO4
  6. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-34a5a9d5c3fc4b3aa2bbca2d61d97570
出典データセット
uspto-grants-1997_04
特許番号
US05624948

反応ノート

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