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Dimethylacetamide → 2-(2,4-Dimethyl-pyrrol-3-yl)-5-benzoylbenzimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylacetamide | HCID 31374 | — |
| 反応物 | 3,4-Diaminobenzophenone | HCID 135520 | — |
| 反応物 | 2,4-Dimethyl-1H-pyrrole-3-carbaldehyde | HCID 21766228 | — |
| 反応物 | Sodium Bisulfite | HCID 23665763 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-(2,4-Dimethyl-pyrrol-3-yl)-5-benzoylbenzimidazole | HCID 57955827 | 81% |
反応手順
3,4-Diaminobenzophenone (1.48 g) and sodium hydrogensulfite (0.87 g) were added to N,N-dimethylacetamide (5 ml) at 130° C., and stirred for 5 minutes. 2,4-Dimethyl-3-formyl-pyrrole (1.03 g) was added and stirred at 130° C. for 8 hours. The reaction mixture was cooled to room temperature and stirred, and after addition of water to reaction mixture, precipitate was collected by filtration, and dried in vacuo to afford 2-(2,4-dimethyl-pyrrol-3-yl)-5-benzoylbenzimidazole (1.78 g, 81%) as a brown solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07951956B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-136f3cc4747b4c07825ffcdecab29380 |
| 出典メモ | uspto-grants-2011_05 |