Acetyl chloride → Methyl 2-(4-formylphenyl)acetate

HRID 553281ノート

反応式

HRID 553281 の反応式
[C:1](Cl)(=O)C.[OH:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([OH:16])=[O:15])=[CH:9][CH:8]=1>CO>[CH3:1][O:15][C:14](=[O:16])[CH2:13][C:10]1[CH:11]=[CH:12][C:7]([CH:6]=[O:5])=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 32834984-(Hydroxymethyl)phenylacetic acid

生成物 1

HCID 19363032Methyl 2-(4-formylphenyl)acetate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Acetyl chloride (5 mL) was added cautiously to solution of (4-hydroxymethylphenyl)acetic acid (5.78 g) in methanol (200 mL), stirred for 18 hours and evaporated. The residue was dissolved in dichloromethane (100 mL) and treated with manganese (IV) oxide (29.47 g), stirred for 18 hours and filtered through Celite. The filter pad was washed with dichloromethane and the combined filtrates evaporated. Purification on silica, eluting with 20% diethyl ether in iso-hexane, afforded the subtitle compound as a white solid (3.60 g).

後処理

  1. customevaporated
  2. dissolutionThe residue was dissolved in dichloromethane (100 mL)
  3. additiontreated with manganese (IV) oxide (29.47 g)
  4. stirringstirred for 18 hours
  5. filtrationfiltered through Celite
  6. washThe filter pad was washed with dichloromethane
  7. customthe combined filtrates evaporated
  8. customPurification on silica
  9. washeluting with 20% diethyl ether in iso-hexane

出典と根拠

ORDレコード
ord-073ae94e62a74aacb8593a2d4ed65733
出典データセット
uspto-grants-2011_05
特許番号
US07951954B2

反応ノート

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