化工社化工社 化学情報印刷レポート · 研究参考用
1-Phenethylamine → Armodafinil
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Phenethylamine | HCID 7408 | — |
| 反応物 | Modafinil acid | HCID 3085267 | — |
| 反応物 | HCID 178514057 | HCID 178514057 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Armodafinil | HCID 9690109 | — |
反応手順
U.S. Pat. No. 4,927,855 describes the preparation of the levorotatory enantiomer of modafinil by chiral resolution of the 2-[(diphenylmethyl)sulfinyl]acetic acid with α-methylbenzyl amine. After recovery and amidation of the enantiomerically pure acid, (−) modafinil was obtained as white crystals by crystallization from ethanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08048222B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-58141b0965b24d8e90d911acee886957 |
| 出典メモ | uspto-grants-2011_11 |